helD [2017-8-11 16:0:3]

DNA 3-5 helicase IV, stimulates [SW|transcription] in an ATP-dependent manner by enhancing transcriptional cycling and elongation

locus: BSU33450

pI: 6.08

mw: 89.74 kDa

protein length: 774 aa

gene length: 2322 bp

function: [SW|transcription], [SW|DNA repair/ recombination]

product: DNA 3-5 helicase IV

essential: no

ec: 3.6.4.12

synonyms: yvgS

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination]
• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins]

Gene

Coordinates: 3,434,327 → 3,436,651

The protein

Protein family

• UvrD subfamily (according to Swiss-Prot)

Structure

• [PDB|3DMN] (C-terminal domain of the protein from ''Lactobacillus plantarum'', 39% identity)

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

additional information

• [protein|4DE90422754DA1FD9EFE58766EACB99CE6171207|HelD] may interact with [SW|RNA polymerase] [pubmed|21710567]

Expression and Regulation

Operons

• genes: [gene|4DE90422754DA1FD9EFE58766EACB99CE6171207|helD]
  description: [Pubmed|22383849]

Biological materials

Mutant

• MGNA-A456 (yvgS::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/456 NBRP B. subtilis, Japan]
• 1A899 ( ''helD''::''erm''), available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A899&Search=1A899 BGSC]
• BKE33450 (''[gene|4DE90422754DA1FD9EFE58766EACB99CE6171207|helD]''::''erm'', available in the BGSC, in [SW|Fabian Commichau]'s, and in [SW|Jörg Stülke]'s lab) [pubmed|28189581]

References

• 24520113,21710567